DicQie Fuller, Ph.D., studies under Dr. Edward Howell, the “Father of Enzyme Therapy,” in search of access to plant or mycelial enzymes in the United States.

Dr. Fuller formulates the “Zyme” product line (DigestZyme, GastroZyme, PureZyme, MasterZyme, CalmZyme, ReleaseZyme, BalanceZyme, and Plantadophilus).*

Her formulations’ popularity is quickly noticed and she begins teaching enzyme nutrition alongside Dr. Howard Loomis for Tony Collier at National Enzyme Company.

Dr. Fuller formulates for several retail companies and teaches across the United States while living in Scottsdale, AZ.


Dr. Fuller returns to private practice and completes her research on enzyme deficiencies based on body type.

Publishes the four Biochemical Individualism Body Typing Booklets for Para, Estro/Testro, Supra, and Neuro.


Transformation™ is established. We are considered the Pioneers of Enzyme Nutrition Therapy for being one of the first to manufacture and distribute plant or mycelial enzymes in the United States.


Wright State University publishes On the Synergistic Effects of Enzymes in Food with Enzymes in the Human Body: A Literature Survey and Analytical Report (PubMed).

Transformation™ expands brand and distributes its enzyme-based dietary supplements to health professionals, clinics, and pharmacies worldwide.


Dr. Fuller moves Transformation™ to Houston, TX, and launches in-house Transformation™ Enzyme Therapy research clinic.


Transformation’s Advisory Board is formed.


Super CellZyme is formulated and introduced by Dr. Dick Couey and Dr. DicQie Fuller.*


Dr. Fuller publishes her first book, The Healing Power of Enzymes.


Mahamane Mamadou, Ph.D., publishes Transformation’s white paper, Oral Enzymes: Facts and Concepts.


Dr. Mamadou and Dr. Fuller formulate Transformation Professional Protocol™ (TPP™) product line of therapeutic strength formulas: Digest, Gastro, Protease, Probiotic, and Lypo.*


Robert Greenberg, Ph.D., DC, FASA and Inventor of the BTA 2000™ introduces Biological Terrain Analysis™ (BTA™) to the clinic and formulates the Biological Terrain Nutritionals™ (BTN™) product line, now incorporated into the TPP™ product line: Adrenal Complex, Liver Support, Thyroid Complex, and Immune AV.*


Transformation™ introduces Carbo-G formula with DPP-IV for gluten and casein sensitivity.*


Transformation’s international network is expanded to twenty-eight countries.

The research study Stability and Activity of Supplemental Digestive Enzymes in Simulated Gastric Fluid is presented at the Scripps Conference by M. Mamadou, S. Marr, K. Paydon, and R. Medhektar.


Dr. Mamadou and KD Couch, NP, research the effects of CalmZyme on neurotransmitters.


Lisa (Helffrich) Hudson, RDN, creates Transformation’s Practitioner’s Product Guide, an exclusive resource for clinicians with more in-depth instructions on usage.

Wendy Everett Cooke with Dr. DicQie Fuller publish The M Club: Survive Menopause and Feel Great Again with the Healing Power of Enzymes.


The Baylor Protease Inflammation Study coordinated by Darryn Willoughby, Ph.D., is published in Medicine and Science in Sports and Exercise (PubMed).


The University of Houston researches the effectiveness of Protease IFC and RepairZyme with their football program, coordinated by Chad Dennis, NSCA, CSCCA.*

Transformation™ launches Private Label program and expands internet retail partnerships.


Lisa (Helffrich) Hudson, RDN, publishes The Ripple Effect of Toxicity: And What You Can Do About It.

Transformation™ introduces its maximum strength Probiotic 42.5 formula.


Suzanne Espinoza purchases Transformation Enzyme Corporation after mentoring with Dr. Fuller and Ken Looney for 16 years.

Transformation’s Zymes 4 Kidz™ line is launched: Kidz Digest Chewables and Kidz Digest Powder.*


Milton Bastidas, DC, CIHP, and Lisa (Helffrich) Hudson, RDN, publish The Effects of Nutrition and Enzyme Therapy on Gastrointestinal Dysfunction, a clinical study that reversed the signs and symptoms of leaky gut (intestinal permeability) in just 63 days using enzyme therapy and diet modifications.


Transformation™ launches Thrive in 63™ Program based on the clinical study led by Dr. Milton Bastidas and Lisa (Helffrich) Hudson, RDN.


Dr. Fuller publishes revised edition of The Healing Power of Enzymes with six additional chapters.

Transformation’s Transcendence™ product line is launched with Dr. Robert Greenberg’s ReZEN formula.*

Transformation™ introduces its spore-based Transbiotic™ formula.*


Transformation’s Transcendence™ product line is expanded to include Dr. Tamyra Comeaux’s FemVita and Privita formulas.*

Dr. DicQie Fuller begins working on the formula for Protease-CBD.*


Amy Rawls, MS, RD, LD, FMNS, CGN, Director of Education and Clinical Services, creates Transformation’s Protocol Pocket Guide.


Transformation™ celebrates 30 Years of Transforming Lives.


Dr. Milton Bastidas begins researching the effects of Protease-CBD on the endocannabinoid system.*


Transformation™ introduces Dr. DicQie Fuller’s final formulation, Protease-CBD.*


Transformation’s commitment to nutrition, health education, and the miracle of enzymes remains strong as ever. The company remains privately held and clinically owned and operated. As a leader in mycelial enzyme research, Transformation™ uses every available resource to stay on the leading edge of clinical nutritional science. With more than 30 years of education and research and an advisory board of clinicians, researchers, educators, and industry leaders guiding us, we remain the pioneers of enzyme nutrition. As a nutritional supplement company, we specialize in the development of high-quality digestive and systemic enzymes, probiotics, and various enzyme-delivered nutritional support products.* Transformation™ formulates and distributes these enzyme-based dietary supplements to health professionals, clinics, and pharmacies worldwide.